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22 Because no head-to-head comparative trials exist, the optimal initial therapy remains uncertain, and treatment selection should be individualized based on cost, access, route of administration, and patient preference regarding route and frequency of administration (oral once per day versus oral twice per day versus subcutaneous injection every 3 months with vitamin A supplementation)

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Whilst mild bloating is relatively common during GLP-1 therapy and often resolves with time and dietary adjustments, certain symptoms warrant prompt medical evaluation